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KMID : 0361019940370010084
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Korean Journal of Otolaryngology - Head and Neck Surgery
1994 Volume.37 No. 1 p.84 ~ p.92
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Staining Patterns of Squamous Cell Carcinomas of the Larynx by Monoclonal Anti-Cytokeratin Antibodies
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도남용
문문만/최봉남/박형욱/이도용/이성재
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Abstract
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Immunohistochemical staining for keratin proteins may be useful as a diagnostic parameter in head and neck neoplasms.
Our study evaluates the keratin antibody staining properties of 27 samples of normal tissues and squamous cell carcinoma of the vocal folds after surgical removal.
In normal epithelia, low molecular weight cytokeratins were strongly positive in basal layer but apparently reduced in suprabasal layers and completely negative in superficial layer. In invasive squamous cell carcinomas, low molecular weight
anti-CK Ab
were positive in all carcinoma cells of poorly differentiated carcinomas.
On the other hand, high molecular weight anti-CK Ab were positive in almost all carcinoma cells of well differentiated carcinomas.
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KEYWORD
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